• A 83-01: Unraveling TGF-β Signaling in Human Intestinal O...

  2025-09-23

  Explore the role of A 83-01, a selective ALK-5 inhibitor, in dissecting TGF-β signaling during human intestinal organoid differentiation. This article delves into how A 83-01 enables precise modulation of cellular pathways in advanced organoid and pharmacokinetic research.

• A 83-01: Advancing Human Intestinal Organoid Research via...

  2025-09-22

  This article explores the utility of A 83-01, a potent ALK-5 inhibitor, in fine-tuning self-renewal and differentiation within human intestinal organoid systems. By examining recent advances in TGF-β signaling pathway manipulation, we highlight novel strategies for enhancing organoid fidelity and scalability in biomedical research.

• A 83-01 in Organoid Modeling: Modulating TGF-β Signaling ...

  2025-09-19

  Explore how A 83-01, a selective TGF-β type I receptor inhibitor, enables precise modulation of stem cell self-renewal and differentiation in advanced organoid systems. This article highlights its mechanistic role and practical applications in epithelial-mesenchymal transition (EMT) research, cellular growth inhibition studies, and the development of scalable, high-fidelity organoid models.

• A 83-01: Advancing Organoid Modeling via Selective TGF-β ...

  2025-09-18

  Explore how A 83-01, a selective TGF-β type I receptor inhibitor, empowers advanced epithelial-mesenchymal transition (EMT) research and refined organoid modeling by precisely modulating Smad-dependent transcriptional pathways.

• br Conflicts of interest br Acknowledgements This

  2025-03-03

  

  Conflicts of interest Acknowledgements This work was sponsored by grants from Longyan University Scientific Research Fund for the Young Scholars (LQ2016010), Middle-aged and Young Teachers Education Research Projects of Fujian Province (JAT170569), Longyan University Scientific Research Fund f

• A decrease in lactate concentration in

  2025-03-03

  

  A decrease in lactate concentration in the incubation medium was observed in samples treated with heparin and 2′,5′-dideoxyadenosine compared with the control (0.05; Fig. 2B). Discussion In the present study we compared the oxidative metabolism and intracellular signals of heparin, the glycosami

• Streptomycetes are a group of filamentous Gram positive soil

  2025-03-03

  

  Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of RN 1734 receptor and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes ar

• m1Ψ-modified Cre mRNA It is well known that the thymus plays

  2025-03-03

  

  It is well known that the thymus plays an important function in the complex pathogenesis and perpetuation of MG. We compared resistin levels between patients with MG with or without thymoma and found that those with thymoma had higher levels than those without thymoma. It has been previously recogni

• An alternative to the agonist or antagonist potential in

  2025-03-03

  

  An alternative to the agonist or antagonist potential in drug discovery is the positive allosteric modulator (PAM) approach, which can augment the normal processes of neurotransmission as opposed to directly replacing or antagonizing them. PAMs are thought to bind to sites that are distinct from the

• The cellular mechanism underlying the CGS mediated

  2025-03-03

  

  The cellular mechanism underlying the CGS12066-mediated inhibition of glutamate release from hippocampal nerve terminals through presynaptic 5-HT1B receptors remains to be elucidated. 5-HT1B receptors are coupled to PTX-sensitive G proteins (Gi or Go) that have been shown to inhibit AC activity as w

• Having taken a step back from affinity to gain

  2025-03-03

  

  Having taken a step back from affinity to gain better exposure and solubility, we started work to replace the unstable oxazolinone, and address the selectivity over the hERG channel. Keeping in mind the binding mode of the series from crystal structures, triazole was identified as another mildly aci

• Pyrimidine is the important pharmacology core in

  2025-03-03

  

  Pyrimidine is the important pharmacology core in many Aurora inhibitors, such as VX-680, ENMD-2076, CYC-116 and ENMD-2076 [12]. To identify additional effective Aurora inhibitors, we designed a series of 2,4-diaminopyrimidine compounds, our modeling studies suggested that the influence of size on Ca

• br Results and discussion br Conclusion In summary a series

  2025-03-03

  

  Results and discussion Conclusion In summary, a series of indazole-based derivatives were synthesized and SAR studies conducted, with view to the development of a novel Aurora kinases inhibitor. The carboxylic loxo 101 group extending from the C-3 position of the aniline and substituted group

• In the case of DIA CN the docking results do

  2025-03-01

  

  In the case of DIA-4CN the docking results do not show any interaction between the iron atom and the inhibitor, presumably due to the reduced ability to form a complex involving the -CONN- moiety versus the bidentate -CONHNH- central group of HYD-4Me. This results in a considerable gap between the i

• br Material and methods br Results br Discussion

  2025-03-01

  

  Material and methods Results Discussion T2D is a substantial threat to global human health [31]. Obesity-associated chronic low-grade inflammation promotes insulin resistance and T2D [32]. In obese individuals, the production of numerous inflammatory molecules including IL-6 and TNF-a is up

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