Likewise the conserved cysteine in the E2

2019-08-21

Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003).

The anxiolytic-like responses produced by

2019-08-20

The anxiolytic-like responses produced by anti-SVG-30 suggests that CRF2 receptors mediate not only the elicitation of anxiety behavior induced by prior stress, i.e.

Nuclear export mediated by CRM1 is initiated

2019-08-19

Nuclear export mediated by CRM1 is initiated by an interaction between RanGTP and the HEAT9 loop of CRM1, triggering a conformational change in the NES binding site that permits NES–cargo protein binding (Dong et al., 2009, Fung and Chook, 2014).

DGKβ [9] is distributed exclusively in

2019-08-17

DGKβ [9] is distributed exclusively in the brain, particularly in the striatum, cerebral cortex, olfactory bulb, and hippocampus [9,10].

In this report we present

2019-08-16

In this report, we present spectroscopic evidence on the effect of different solvents having proton acceptor and proton donor ability and pH of the medium on the abstraction of amino proton of PI (Scheme 1) for controlling the nonradiative rates.

Autophagy is a degradation pathway

2019-08-15

Autophagy is a degradation pathway existing in all eukaryotic organisms. It is the main system for the degradation of bulk cytoplasmic components in cells (Feng et al., 2014), but it also plays a crucial role in other processes, as immunity (Wileman, 2013), mitochondrial (Dengjel and Abeliovich, 2014) and peroxisomal (Till et al., 2012) degradation and clearance of misfolded protein PPACKII (Lamark and Johansen, 2012).

Inhibition of DHODH is reflected by

2019-08-14

Inhibition of DHODH is reflected by an antiproliferative effect on peripheral blood mononuclear Enfuvirtide (PBMCs), which can be measured by the inhibitory effect on their phytohemagglutinin (PHA) stimulated growth.

In humans several different small

2019-08-13

In humans, several different small ubiquitin-related modifier (SUMO) paralogs can be conjugated to cellular proteins.

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2018-07-29