• Herbal medicines have been used to treat

  2025-02-20

  

  Herbal medicines have been used to treat various types of diseases and disorders for thousands of years worldwide (Li and Brown, 2009). Natural products have been the remedy of cancer chemotherapy for the past several decades. Anisomeles indica (L.) Kuntze. (Labiatae), commonly known as 'yu-chen-tsa

• The first and the best characterized mechanism of receptor d

  2025-02-19

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic p-selectin receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional molecules su

• With regard to participation of the

  2025-02-19

  

  With regard to participation of the 12S-lipoxygenase in diabetes mellitus, inconsistent results have been obtained. Earlier studies demonstrated that the leukocyte-type 12S-lipoxygenase is specifically expressed in pancreatic b-cells and is involved in regulating glucose-stimulated insulin secretion

• One of the specifications of

  2025-02-19

  

  One of the specifications of the NIA-AA research framework was that it A-71623 be applicable in two distinct research contexts—interventional trials and observational research. In many if not most modern AD interventional trials, individuals are selected for inclusion with the aid of biomarkers. Th

• br Conflicts of interest br Acknowledgements This work

  2025-02-19

  

  Conflicts of interest Acknowledgements This work was sponsored by grants from Longyan University Scientific Research Fund for the Young Scholars (LQ2016010), Middle-aged and Young Teachers Education Research Projects of Fujian Province (JAT170569), Longyan University Scientific Research Fund f

• Involvement of Adiponectin in the regulation of imatinib res

  2025-02-19

  

  Involvement of Adiponectin in the regulation of imatinib resistance in human CML cells has not been hitherto examined. Therefore, in this study, we first established imatinib-resistant K562 CML cells, and then evaluated the effect of Adiponectin in reversing imatinib resistance. The data presented h

• Mast cells Mast cells are immune cells of the

  2025-02-19

  

  Mast cells. Mast T 705 are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination [75]. Moreover, mast cel

• Does dietary caffeine interfere with antinociception by othe

  2025-02-19

  

  (8) Does dietary caffeine interfere with antinociception by other modalities that alter pain (TENS, exercise, joint mobilization, water immersion therapy)? Caffeine and/or A1R antagonists inhibit antinociception by each of these modalities in preclinical studies, such that there is potential for int

• Serum soluble sCD is a shedding

  2025-02-19

  

  Serum soluble sCD21 is a shedding product from the ectodomain of membrane CD21 after B cell activation (Masilamani et al., 2003, Masilamani et al., 2004a, Masilamani et al., 2004b, Grottenthaler et al., 2006, Hoefer et al., 2008), which resembles the ligand-binding capacity of intact CD21 (Wu et al.

• Similar to V the temporal neocortex of mammals including

  2025-02-18

  

  Similar to V1, the temporal neocortex of mammals, including the primary auditory cortex (A1), is densely innervated by 5-HT fibers originating mainly in the dorsal raphe nucleus (Campbell et al., 1987, Harding and Paxinos, 2004, Törk, 1990), and the major PF-00562271 synthesis of 5-HTRs are express

• In conclusion AXL overexpression preexisted

  2025-02-18

  

  In conclusion, AXL overexpression preexisted in a subgroup of treatment-naive lung adenocarcinoma specimens harboring an activating EGFR mutation or in those with wild-type EGFR. Anti-AXL therapeutics delivered up front in combination with the EGFR inhibitor might overcome intrinsic or acquired resi

• br Conclusion br List of abbreviations br Acknowledgment

  2025-02-18

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

• br Results and discussion br Conclusion

  2025-02-18

  

  Results and discussion Conclusion A series of aminobenzothiazole derivatives were investigated as possible Aurora B kinase inhibitors. Bioisosteric replacement of the heterocyclic core of the lead compound was performed regarding the docking analysis. Replacement of the oxygen Glycogen phospho

• br Introduction The vacuolar ATPases

  2025-02-18

  

  Introduction The vacuolar ATPases (V-ATPases) are ATP-driven proton pumps that play important roles in both normal and disease processes [1], [2], [3], [4], [5]. V-ATPases within cells function in such processes as intracellular membrane traffic, protein processing and degradation, coupled transp

• br Results br Discussion br Conclusion The flux of glucose

  2025-02-18

  

  Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta serine protease in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway

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