• Perturbation in the cytokine network

  2020-10-17

  

  Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg

• Prostaglandins production and some of their possible biologi

  2020-10-17

  

  Prostaglandins production and some of their possible biological functions have been reported in protozoa, helminths, and fungi organisms, for example amphizoic amoebas of the genus Acanthamoeba and Entamoeba (E. histolytica) produce PGA2, PGE2 and PGF2α [5,6]. PGA2 is believed to be an intrinsic osm

• Almost all previously published haplotype

  2020-10-17

  

  Almost all previously published haplotype association studies have demonstrated the importance of haplotype reconstruction because the combinations of SNPs exert synergistic effects on protein function. Even synonymous polymorphisms within haplotypes can have functional consequences that are drastic

• br Functional significance Defects of the lysyl hydroxylases

  2020-10-16

  

  Functional significance Defects of the lysyl hydroxylases LH1, LH2, and LH3 impair collagen secretion and stability in the extracellular matrix, and cause rare connective tissue disorders such as Ehlers-Danlos type-VI [27], Bruck syndrome [28], and skeletal dysplasia [29], respectively. Elucidati

• Acknowledgments br Introduction Steroidogenesis the process

  2020-10-16

  

  Acknowledgments Introduction Steroidogenesis, the process of testosterone synthesis, occurs in the adrenal cortex, testis and ovary, and it is controlled by luteinizing hormone (LH), which is synthesized and secreted from the pituitary (Hanukoglu, 1992, Payne and Youngblood, 1995). In the testis

• Introduction Psoriasis is a chronic recurrent and inflammato

  2020-10-16

  

  Introduction Psoriasis is a chronic, recurrent and inflammatory skin disease, and it is characterized by erythema, skin hyperplasia, scales, and hyperproliferation of keratinocyte [1]. It is reported that the psoriasis occurrences are about 3% worldwide [2], but the number varies depending on ethni

• Phenolic compounds generated during biomass pretreatment inh

  2020-10-16

  

  Phenolic compounds generated during VO-Ohpic trihydrate mg pretreatment inhibit and/or deactivate cellulolytic/hemicellulolytic enzymes as well as the viability and fermentative capacity of yeast and bacteria [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. Phenolic compounds cause changes in p

• Among the high value compounds derived from agricultural

  2020-10-16

  

  Among the high value compounds derived from agricultural residues there are enzymes with industrial application. The extraction processes have been focused on the development of new strategies that guarantee high recovery rates with maximum activity (Nadar et al., 2017). The residues of these two fr

• (±)-CPSI 1306 Although many of the hepatic responses ob

  2020-10-16

  

  Although many of the hepatic responses observed on the first day of recovery attenuated over the course of the recovery period, minimal-to-mild centrilobular hepatocellular hypertrophy tended to persist. Mean absolute and relative liver weights had returned to control levels after 28 days of recover

• Similar to EGFR another receptor tyrosine kinase

  2020-10-16

  

  Similar to EGFR, another receptor tyrosine kinase (RTK), fibroblast growth factor receptor 4 (FGFR4), is gaining attention in the lung cancer setting. The protein expression of this receptor has been recently associated with a negative impact on lung cancer prognosis, supporting the idea that FGFR4

• Exposure to ultraviolet radiation with

  2020-10-16

  

  Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr

• br Experimental Procedures br Author Contributions br Acknow

  2020-10-16

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility po1 have been identified in many of these regions [2]. How these genes exert their functio

• br Asb Proteins and Mitochondrial

  2020-10-16

  

  Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic SAG supplier and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate a plethora of pr

• PD 0332991 br Materials and methods br Results

  2020-10-16

  

  Materials and methods Results Discussion The investigation of oxysterols is highly complex and challenging, arising not only from the large number of molecules in this family, but also due to their low abundance in biological systems compared to cholesterol and their susceptibility for auto

• Autophagy is a degradation pathway existing in

  2020-10-16

  

  Autophagy is a degradation pathway existing in all eukaryotic organisms. It is the main system for the degradation of bulk cytoplasmic components in cells (Feng et al., 2014), but it also plays a crucial role in other processes, as immunity (Wileman, 2013), mitochondrial (Dengjel and Abeliovich, 201

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