• PKA signalling in the nucleus was thought

  2020-10-20

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the nuciferine to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and fu

• Since the initial identification of DNA ligase inhibitors

  2020-10-20

  

  Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the

• The transcriptome analysis of barley seeds

  2020-10-20

  

  The transcriptome analysis of barley seeds in two tissue fractions: starchy endosperm/aleurone and embryo/scutellum, during maturation, desiccation and germination, revealed the large group of GA-responsive genes (Sreenivasulu et al., 2008). These transcripts have been divided into two groups. Nearl

• We have previously disclosed the discovery

  2020-10-19

  

  We have previously disclosed the discovery of a 7-azaindole-3-acetic CRT0044876 receptor CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of th

• br Author contributions br Conflicts of interest

  2020-10-19

  

  Author contributions Conflicts of interest Introduction Current the 5-year survival rates for lung and pancreatic cancers are 18% and 8%, respectively. These low survival rates are partially because of the late diagnosis of one-half of cases, in which 5-year survival decrease to 4% and 3%,

• Materials and methods br Results br Discussion Hydroxylation

  2020-10-19

  

  Materials and methods Results Discussion Hydroxylation of proline in bacterial Levodopa is one of the oxygen-requiring metabolic reactions, which needs efficient oxygen. Oxygen supply is always a rate-limiting step for tyrosinase production even though pure oxygen is purged in a bioreactor (3

• Cx platin could improve the level of cellular uptake and

  2020-10-19

  

  Cx-platin could improve the level of cellular uptake and DNA platination, hence triggering distinct DNA damage repair pathways. The data (Fig. 3B, C and D) demonstrated that Cx-platin could increase the foci number of γH2AX in cancer cells, preventing the efficient DSBs repair. This gives a good exp

• Evidence for interactions between the endothelin and the ang

  2020-10-19

  

  Evidence for interactions between the endothelin and the angiotensin system has also become plentiful. It has become clear that the two systems, in addition to acting independently, can act synergistically (Emori et al., 1989, Imai et al., 1992) as well as promote the peptide mRNA expression in endo

• br Results br Discussion In

  2020-10-19

  

  Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 liothyronine sodium via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub

• br Expression and Tissue Functions of DDRs The DDRs are

  2020-10-19

  

  Expression and Tissue Functions of DDRs The DDRs are widely expressed in different tissues, both during development and in adult organisms. DDR1 mRNA is found in many tissues in mice and humans, with high levels in brain, lung, kidney, spleen, and placenta (Di Marco et al., 1993, Johnson et al.,

• In addition to playing important

  2020-10-19

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the HPF synthesis of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a). M

• Diacylglycerol kinases DGK and are lipid

  2020-10-17

  

  Diacylglycerol kinases (DGK) α and ζ are lipid kinases that limit diacylglycerol (DAG)-dependent activation pathways downstream of the TCR (Merida et al., 2015). Their upregulation in tumor infiltrating lymphocytes (TIL) has been linked to generation of hyporesponsive states that contribute to immun

• 9-Phenanthrol DGK deficiency caused a significant increase i

  2020-10-17

  

  DGKδ deficiency caused a significant increase in the SERT protein level, but its mRNA level was not affected (Fig. 1). These results suggest that SERT protein stability is directly reduced by interaction with the DGKδ protein. In contrast, DGKδ deficiency regulated both TPH-2 and MAO-A protein and m

• br Introduction Lycium barbarum also known

  2020-10-17

  

  Introduction Lycium barbarum, also known as wolfberry, belongs to the plant family Solanaceae. Red-coloured fruits of L. barbarum are used as traditional Chinese herbal medicine to promote health and longevity and as a food supplement for thousands of years [1]. They possess many biological activ

• The CysLT receptor antagonist BayCysLT RA

  2020-10-17

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear Fmoc-D-Lys(Boc)-OH into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Bar

13212 records 688/881 page Previous Next First page 上5页 686687688689690 下5页 Last page