• Others demonstrated that Paneth cells maintain stem

  2022-04-16

  

  Others demonstrated that Paneth cells maintain stem cell function and crypt homeostasis by providing metabolic lactate to sustain the enhanced mitochondrial oxidative phosphorylation in the Lgr5+ ISCs (Rodriguez-Colman et al., 2017), which substantially agrees with our findings in this study. Furthe

• br Conflict of Interest Both GM and BDH

  2022-04-16

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• During the structural transition the FD the PHD and

  2022-04-16

  

  During the structural transition, the FD, the PHD and the TrD retain their tertiary structure. Nevertheless, they undergo large rearrangements in their relative orientation due to secondary changes in hinge segments (R1 to R5) which refold during the low-pH induced conformational change. Particularl

• br STAR Methods br Introduction Glycosylation is one of the

  2022-04-16

  

  STAR★Methods Introduction Glycosylation is one of the most prevalent post-translational modifications of proteins. It not only plays major roles in folding, transport and localization of proteins [1], but also regulates various biological processes such as cell growth, viral replication and im

• In conclusion we have designed and

  2022-04-15

  

  In conclusion, we have designed and characterized a novel series of EAAT-blockers, exemplified by (-[4-(2-bromo-4,5-difluorophenoxy)phenyl]--asparagine)—a potent, selective, competitive non-substrate inhibitor of EAAT-2. As one of the most potent and selective EAAT-2 inhibitors identified to date,

• Glutamate is a ubiquitous principal excitatory neurotransmit

  2022-04-15

  

  Glutamate is a ubiquitous principal excitatory neurotransmitter in the Recent data from that plays a central role in a variety of brain functions (Delgado, 2013, Hawkins, 2009). Several studies reported that CSF glutamate was associated with mental illness, including major depressive disorder, anxi

• wnt inhibitor Hippocampal lesioned mice were less able to w

  2022-04-15

  

  Hippocampal-lesioned mice were less able to withhold responding during a DRL-10 requirement (i.e. when the animals had to wait 10s between lever presses), and were thus less efficient than sham operated controls. In contrast, GluR-A−/− mice did not differ from wild-type mice when the DRL requirement

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2022-04-15

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by protease inhibitors deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximate

• Cx mimetic peptides short synthetic peptides corresponding t

  2022-04-15

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino parecoxib sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concent

• The histamine H receptor H

  2022-04-15

  

  The histamine H3 receptor (H3R; 326–445 amino-acids) is located on histaminergic neuron somata, dendrites and axon varicosities, as well as on the axon varicosities and somata of other neurons, providing negative feedback to inhibit histamine synthesis and the release of histamine or other transmitt

• CCK Octapeptide, non-sulfated australia The measured ROcc va

  2022-04-15

  

  The measured ROcc50 values (4.8 and 42 mg/kg, respectively) were lower than those estimated from the mouse free CCK Octapeptide, non-sulfated australia concentrations (0.4 and 9.3 mg/kg for the sigma-1 and histamine H3 receptor, respectively) or rat CSF levels (0.65 and 4.5 mg/kg, respectively). Thi

• br Materials and methods br Results br Discussion Several hi

  2022-04-15

  

  Materials and methods Results Discussion Several histamine H3 receptor antagonists have progressed into clinical development for indications including Alzheimer's disease, schizophrenia, pain and narcolepsy. Each of the compounds studied herein has been extensively characterized in its own

• In conclusion we demonstrate for the first time that

  2022-04-15

  

  In conclusion, we demonstrate, for the first time, that histamine plays a key role in regulating astrocyte function and gliotransmitter release, and we now must re-consider the roles of monoamine neurotransmitters in brain function in the context of astrocyte signalling. Further in vivo studies will

• Glutathione transferases EC also referred to as glutathione

  2022-04-14

  

  Glutathione transferases (EC 2.5.1.18; also referred to as glutathione S-transferases, GSTs) are ubiquitous and promiscuous enzymes that catalyze various kinds of reactions involving a wide variety of substrates that are toxic and chemically reactive (Angelucci et al., 2005). The primary function of

• GPR is present primarily in

  2022-04-14

  

  GPR119 is present primarily in the pancreas and the intestine. Activation of GPR119 increases insulin, GLP-1, GIP and PYY secretion. GPR119 agonists stimulate insulin release in a glucose-dependent manner. The glucose dependent insulin secretion (GIDS) mechanism makes GPR119 an attractive target for

12868 records 417/858 page Previous Next First page 上5页 416417418419420 下5页 Last page