• Our results show that deletion of the

  2022-04-20

  

  Our results show that deletion of the first loop of Obg does not abolish the augmentation of the GTPase activity of CgtAvc, revealing that the first loop is mainly responsible for the anchoring of the protein in the 50S and the transient interaction with ribosome is enough for augmentation of GTPase

• Alzheimer s disease AD is

  2022-04-20

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

• br Materials and methods br Results

  2022-04-20

  

  Materials and methods Results Discussion GPR35 expression has been identified within discrete regions of the nervous system, including the spinal cord [[43], [44], [45], [46], [47], [48]]. Importantly, GPR35 is expressed not only in neurons but also in spinal glial cells [43]. Unfortunately

• A subsequent modeling study by a different group

  2022-04-20

  

  A subsequent modeling study by a different group was based on the bovine rhodopsin homology model using the 1L9H construct [38]. However, the site-directed mutagenesis data and docking suggested that the niacin-binding pocket is different to that described in the aforementioned report, but similar t

• Recently a G protein coupled receptor

  2022-04-20

  

  Recently, a G-protein-coupled receptor, GPR109a, was identified as a molecular target for niacin. Following this breakthrough, our group initiated a drug discovery program focused on the development of a high affinity ‘flush-free’ niacin-like agonist. Previously, we reported on the identification of

• The activation of the ERK pathway participates

  2022-04-20

  

  The activation of the ERK pathway participates in the transmission of pain signaling by sensitizing primary afferents (Ji et al., 2009, Lai et al., 2011). Thus, the blockade of ERK activation in the primary sensory Radicicol can reduce the mechanical hypersensitivity and the thermal hypersensitivit

• br Introduction Atherothrombosis is associated with the pres

  2022-04-20

  

  Introduction Atherothrombosis is associated with the presence of a low-grade, subclinical smoldering inflammatory response [1]. Several inflammatory markers, among them high-sensitive C-reactive protein (hs-CRP) [2], the erythrocyte sedimentation rate (ESR) [3], fibrinogen concentrations [4], int

• br Introduction L Glutamate is one of the most prevalent

  2022-04-20

  

  Introduction L-Glutamate is one of the most prevalent excitatory signaling molecules in the central nervous system (CNS) (Salazar et al., 2016) and plays a crucial role in a variety of Cy5.5 carboxylic acid (non-sulfonated) functions such as memory and learning (Danbolt, 2001, Nedergaard et al.,

• Hypertriglyceridemia is associated with an overproduction

  2022-04-19

  

  Hypertriglyceridemia is associated with an overproduction and secretion of triglyceride-rich lipoproteins (TRLs), due to increased liver lipid substrate availability (Adiels et al., 2005, Choi and Ginsberg, 2011), and/or reduced catabolism of TRLs and their remnants, due to reduced lipoprotein lipas

• Serotonin hydroxytryptamine HT is a monoamine with dual func

  2022-04-19

  

  Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine with dual functions in the developing and matured brain. 5-HT regulates development of the KJ Pyr 9 as a neurotrophic factor and is involved in emotion and cognition as a neurotransmitter in adulthood (Gaspar et al., 2003; Daubert and Condron, 201

• With the nitrogen containing heterocycle components and

  2022-04-19

  

  With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic Sitagliptin phosphate (, and ), followed by deprotection by TFA, smoothly

• ampk pathway In the current study we

  2022-04-19

  

  In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi

• Earlier we have showed that tumor associated sFas mRNA

  2022-04-19

  

  Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is

• br Mammalian chromosomal DNA binds

  2022-04-19

  

  Mammalian chromosomal DNA binds to various proteins and the DNA-protein complexes form DNA packaging units, called nucleosomes. Histones are the chief protein components of nucleosomes and perform pivotal functions in chromosomal gene regulation. Moreover, many types of chemical modifications of h

• A compound structurally similar to PF

  2022-04-19

  

  A SAR-302503 structurally similar to PF-03654746 has been developed by Pfizer (PF-03654764), with a minor change in the substituent attached to the cyclobutanecarboxamide moiety (Wager et al., 2011). This compound, with the chemical name trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N

12868 records 414/858 page Previous Next First page 上5页 411412413414415 下5页 Last page